Synthetic Biology Consortium Meeting Information

The 2022 Synthetic Biology Consortium Meeting will be hosted virtually on December 14, 2022 from 10:30am - 6:00pm (EST). 

Watch the meeting recording here

The Synthetic Biology Consortium meets annually to facilitate important discussions focused on synthetic biology and cultivate a culture of synthetic biology research at the NIH. The 2022 Synthetic Biology Consortium Meeting will continue to facilitate networking and collaboration among synthetic biology investigators and NIH program directors. This year’s meeting will focus on control theory approaches to create robust synthetic biology technologies that are safe and predictable, especially in the context of human health. Prior to this meeting, the Synthetic Biology Consortium will also be hosting four (4) breakouts focused on specific topics within control theory. Please see the breakout topic descriptions below and register for these breakout sessions.

 

Breakout: Control Theory and Toolkits and Modeling

Time: November 18, 2022; 6:00pm - 8:00pm (EST) Watch the meeting recording here

Leads: Josh Leonard, Northwestern and Jermont Chen, NIBIB

Description: Development of engineered living systems for diverse application is increasingly enabled by the generation of well-characterized and reconfigurable “parts”, by computation modeling that facilitates both interpretation and design, and by importation of conceptual and analytical tools from mature technical disciplines such as control theory. In this breakout, we will consider state-of-the-art understanding, immediate opportunities, and long-term goals for catalyzing the next generation of synthetic biology research to enable biomedicine.

 

Breakout: Engineering Biology Capabilities and Bottlenecks

Time: November 30, 2022; 1:00pm - 4:00pm (EST) Watch the meeting recording here

Leads: Domitilla Del Vecchio, MIT and Tuba Fehr, NICHD

Description: How much has the field of synthetic biology progressed to predict genetic circuit behavior? How can we learn from biology to design more robust and reproducible engineered biological systems? What are the bottlenecks we need to overcome to make engineered cells for therapeutic purposes?

 

Breakout: Responses to the Pandemic and Opportunities for Synthetic Biology to Prepare and Recover from a Pandemic

Time: December 5, 2022; 3:00pm - 5:00pm (EST) Watch the meeting recording here

Leads: Katie Galloway, MIT and Brigitte Sanders, NIAID

Description: The development and application of synthetic vaccines has recently been developed and tested. How can we leverage synthetic biology for pandemic preparedness? How can we respond to emerging and acute pandemic challenges in the short-term? How do we develop synthetic biology for therapeutic applications? How can we use synthetic biology to recover and restore health outcomes following a pandemic? A discussion of strategies that can be deployed for challenges over different timescales from short-term to long-term to support health and recovery from a pandemic will be discussed.

 

Breakout: Scaling up Biocontrol Methods to Complex Biological Systems

Time: December 6, 2022; 12:00pm - 2:30pm (EST) Watch the meeting recording here

Leads: Marcella Gomez, UCSC and Eric Johnson, NCI

Description: Generating predictive models for biological systems has been a persistent barrier to the design of complex systems. Can robust control be achieved without a predictive mechanistic model? Challenges in monitoring biological response in real-time and effective timescales. Does the feedback computation need to be as fast as the fastest biological process being monitored?

 

Agenda: 2022 Virtual Synthetic Biology Consortium Meeting

December 14, 2022; 10:30am - 6:00pm (EST)

Time Session
10:20am - 10:30am Meeting Opens: Welcome, Introduction, and Schedule of Events
10:30am - 10:40am

Welcoming Remarks

Dinah Singer, NCI, Deputy Director for Scientific Strategy and Development

10:40am - 11:00am

Introduction to Control Theory and Synthetic Biology

Domitilla Del Vecchio, Massachusetts Institute of Technology

11:00am - 11:45am

Research Presentation and Breakout Summary: Engineering Biology Capabilities and Bottlenecks

Domitilla Del Vecchio, Massachusetts Institute of Technology

11:45am - 12:30pm

Research Presentation and Breakout Summary: Responses to the Pandemic and Opportunities for Synthetic Biology to Prepare and Recover from a Pandemic

Katie Galloway, Massachusetts Institute of Technology

12:30pm - 12:45pm Break
12:45pm - 1:30pm

Research Presentation and Breakout Summary: Control Theory and Toolkits and Modeling

Josh Leonard, Northwestern University

1:30pm - 2:15pm

Research Presentation and Breakout Summary: Scaling up Biocontrol Methods to Complex Biological Systems

Marcella Gomez, UC Santa Cruz

2:15pm - 2:20pm

Closing Remarks

David Rampulla, NIBIB, Division of Discovery Science and Technology (Bioengineering)

2:20pm - 2:30pm Introduction to Gather.Town
2:30pm - 6:00pm

Virtual Poster Session and Networking Session on Gather.Town

Room 1: Virtual Poster Session*

Poster Session A: 2:30pm - 4:00pm

Poster Session B: 4:00pm - 5:30pm

Room 2: Engage with NIH Program Staff

Meet with NIH program staff from various Institutes/Centers as well as the NIBIB Training Division to discuss your research, grant mechanisms, and IC missions.

Room 3: Virtual Networking Session

*If you are interested in presenting a poster during the virtual poster session, please submit your poster abstract for approval by November 21st to nihsynbio@mail.nih.gov. You will be notified of your poster's acceptance via email by November 28th, at which time you may also indicate your preferred presentation window (2:30pm - 4:00pm or 4:00pm - 5:30pm). The poster acceptance email will also provide additional instructions for formatting/re-sizing your poster for the virtual session. 

2021

2021 Synthetic Biology Consortium Meeting Summary

2021 Synthetic Biology Consortium Meeting Videos

2021 NIH Synthetic Biology Consortium Meeting – Day One:

 

2021 NIH Synthetic Biology Consortium Meeting – Trainee Grant/Technical Writing Session:

 

2021 NIH Synthetic Biology Consortium Meeting – Day Two:

 

2021 Synthetic Biology Consortium Meeting Agenda

*Please note that all agenda times and sessions are tentative and are subject to change from the meeting organizers. 

Day 1: November 4, 2021 (all times are Eastern Daylight Time)

Time

Session

11:00am - 11:15am

Welcoming Remarks

Dave Rampulla, NIBIB, Division of Discovery Science and Technology (Bioengineering)

11:15am - 12:45pm

Parallel Sessions
 

Collaborative Approaches to Engineer Biology for Cancer Applications - Principal Investigators

Discussion of awarded projects and consortium connections followed by interactive Q&A session with panel speakers. 

Moderator: Michelle Berny-Lang, NCI, Center for Strategic Scientific Initiatives

Presentations:

AND-gated Synthetic Biomarkers for Early Detection of Liver Metastasis, Gabriel Kwong, Georgia Institute of Technology

Synthetic circuits that drive infiltration of therapeutic T cells into immunologically cold tumors, Wendell Lim, University of California, San Francisco

Personalization and Failure Testing of Dual Switch Gene Drives in Lung Cancer, Justin Pritchard, Pennsylvania State University

Immunotherapy via engineered therapeutic programs in tumors using RNA, Darrell Irvine, Massachusetts Institute of Technology

Precise tumor targeting with logic CAR circuits, Wilson Wong, Boston University

Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer, Amir Zarrinpar, University of California, San Diego

Grant/Technical Writing Session - Trainees

Discussion of T's, K's, and F's and how these are different from other research grants followed by interactive Q&A session with panel speakers. 

Manana Sukhareva, NIBIB, Office of Scientific Review

Leslie Frieden, NIDCR, Research Training & Career Development Branch

12:45pm - 1:00 pm

Break

1:00pm - 1:45pm

Synthetic Biology at the NIH: Overview

Brief presentations from NIH ICs with interest in synthetic biology.

1. NIBIB

  • Dave Rampulla, NIBIB, Division of Discovery Science and Technology (Bioengineering)

  • Tatjana Atanasijevic, NIBIB, Division of Applied Science and Technology (Bioimaging)

2. NCCIH

  • Hye-Sook Kim, NCCIH, Basic and Mechanistic Research

3. NCI

  • Kelly Crotty, NCI, Center for Strategic Scientific Initiatives

4. NHGRI

  • Stephanie Morris, NHGRI, Division of Genome Sciences

5. NHLBI

  • Rahul Thakar, NHLBI, Advanced Technologies and Surgery Branch

6. NIA

  • Ronald Kohanski, NIA, Division of Aging Biology

7. NIAID

  • Brigitte Sanders, NIAID, Division of AIDS

8. NICHD

  • Tuba Fehr, NICHD, Development Biology and Structural Variation Branch

9. NIGMS

  • Michelle Bond, NIGMS, Division of Pharmacology, Physiology, and Biological Chemistry

10. BRAIN

  • Ryan Richardson, NINDS, Office of the BRAIN Director

1:45pm - 2:00pm

Break

2:00pm - 3:00pm

NIH IC "Office Hours"

Talk with Program Officers about your research, grant mechanisms, and IC missions. 

1. NIBIB

  • Dave Rampulla, NIBIB, Division of Discovery Science and Technology (Bioengineering)

  • Tatjana Atanasijevic, NIBIB, Division of Applied Science and Technology (Bioimaging)

2. NCCIH

  • Hye-Sook Kim, NCCIH, Basic and Mechanistic Research

3. NCI

  • Jerry Li, NCI, Structural Biology and Molecular Applications Branch

  • Kelly Crotty, NCI, Center for Strategic Scientific Initiatives

  • Michelle Berny-Lang, NCI, Center for Strategic Scientific Initiatives

4. NHGRI

  • Stephanie Morris, NHGRI, Division of Genome Sciences

5. NHLBI

  • Rahul Thakar, NHLBI, Advanced Technologies and Surgery Branch

6. NIA

  • Ronald Kohanski, NIA, Division of Aging Biology

7. NIAID

  • Brigitte Sanders, NIAID, Division of AIDS

  • Reed Shabman, NIAID, Division of Microbiology and Infectious Diseases

8. NICHD

  • Tuba Fehr, NICHD, Development Biology and Structural Variation Branch

9. NIGMS

  • Michelle Bond, NIGMS, Division of Pharmacology, Physiology, and Biological Chemistry

10. BRAIN

  • Ryan Richardson, NINDS, Office of the BRAIN Director

 

Day 2: November 5, 2021 (all times are Eastern Daylight Time)

Time

Session

11:00am - 11:15am

Welcoming Remarks

Michelle Berny-Lang, NCI, Center for Strategic Scientific Initiatives

11:15am - 12:00pm

Keynote: Designing Intelligent Cell and Gene Therapies

Tim Lu, Massachusetts Institute of Technology

Gary Lee, Senti Biosciences

12:00pm - 12:15pm

Break

12:15pm - 1:00pm

Synthetic Biology Consortium Showcase: Part I

Moderator: Nichole Daringer, Rowan University

  Engineered cells for in situ synthesis of therapeutic proteins, Parijat Bhatnagar, SRI International
  Engineering cell-based therapies that sense and modulate the tumor microenvironment, Joshua Leonard, Northwestern University
  Advancing therapeutics by reprogramming cells to direct cell fate outcomes, Tara Deans, The University of Utah
  Q&A Panel 

1:00pm - 1:45pm

Synthetic Biology Consortium Showcase: Part II

Moderator: Jiahe Li, Northeastern University

  Regulated Microbial Production of DOPA, Andrew Ellington, University of Texas at Austin
  Predicting and controlling the human gut microbiome, Ophelia Venturelli, University of Wisconsin-Madison
  Engineering bacteria for cancer therapy, Tal Danino, Columbia University
  Q&A Panel

1:45pm - 2:00pm

Break

2:00pm - 2:45pm

Keynote: FDA's Role in Biological Product Review and Development

Karen Elkins, FDA, Center for Biologics Evaluation and Research

Carolyn Yong, FDA, Center for Biologics Evaluation and Research

2:45pm - 3:00pm

Closing Remarks

Dave Rampulla, NIBIB, Division of Discovery Science and Technology (Bioengineering)

 

2019

Agenda 2019

Day 1: October 28, 2019

Time

Session

Room Assignment

8:00am - 8:40am

Registration

Lower Level Lobby

8:40am - 9:00am

Welcoming Remarks

Bruce Tromberg, NIBIB Institute Director

Room E1/E2

9:00am - 9:45am

Keynote Speaker

Challenges and Opportunities for Mammalian Synthetic Biology

Ron Weiss, Massachusetts Institute of Technology 

Room E1/E2

 

Part 1:

9:45am - 10:45am

 

Break:

10:45am - 11:00am

 

Part 2:

11:00am - 12:00pm

Breakout Session I

 

Embryogenesis & Morphogenesis

Room C1/C2

Moderator: Ahmad Khalil, Boston University

NIH Program Officer(s): Mahua Mukhopadhyay, (NICHD) & Tuba Fehr (NICHD)                        

 

 

Natural Products

Room E1/E2

 

Moderator: Mary Dunlop, Boston University

NIH Program Officer(s): Craig Hopp (NCCIH) 

 

 

 

 

Vaccine Development

Room G1/G2

 

Moderator: Julius Lucks, Northwestern University

NIH Program Officer(s): Brigitte Sanders (NIAID) & Karen Lacourciere (NIAID)        

 

 

 

Immunotherapy

Room F1/F2

 

Moderator: Josh Leonard,  Northwestern University

NIH Program Officer(s): Kevin Howcroft (NCI) 

 

 

 

 

 

*Please see room assignments under breakout session topic

12:00pm - 1:00pm Networking Lunch (Optional) Room A/B

1:00pm - 2:30pm

Grant/Technical Writing Session - Principal Investigators

Room E1/E2         

Presentation: Discussion of different funding mechanisms (R01s, R03s, and R21s), application process, and peer-reviewed process

Craig Giroux, NIH Scientific Review Officer

Panel Discussion: Interactive Q&A session with panel speakers

Craig Giroux, NIH Scientific Review Officer
Josh Leonard, Northwestern University
David Rampulla, NIBIB Program Director

Grant/Technical Writing Session - Trainees          

Room F1/F2                                               

Presentation: Discussion of T's, K's, and F's and how these are different from other research grants                                                                                 

Manana Sukhareva, NIBIB Director, Office of Scientific Review
Tiffani Bailey Lash, NIBIB Program Director

Panel Discussion: Interactive Q&A session with panel speakers

Manana Sukhareva, NIBIB Director, Office of Scientific Review
Tiffani Bailey Lash, NIBIB Program Director

 

 

 

*Please see room assignments under breakout session topic

2:30pm - 3:00pm

Break

Lobby

3:00pm - 5:00pm

Poster Session

Atrium

 

Day 2: October 29, 2019

Time

Session

Room Assignment

8:00am - 8:30am

Registration

Lower Level Lobby

8:30am - 8:40am

Welcoming Remarks

David Rampulla, NIBIB Program Director

Room E1/E2

 

 

Part 1:

8:40am - 9:40am

 

Break:

9:40am - 10:00am

 

Part 2:

10:00am - 11:00am

Breakout Session II

 

Embryogenesis & Morphogenesis

Room C1/C2

Moderator: Tara Deans, University of Utah

NIH Program Officer(s): Mahua Mukhopadhyay (NICHD) & Tuba Fehr (NICHD)    

 

 

 

Natural Products

Room E1/E2

 

Moderator: Mary Dunlop, Boston University

NIH Program Officer(s): Craig Hopp (NCCIH) 

 

 

Vaccine Development

Room G1/G2

 

Moderator: Julius Lucks, Northwestern University

NIH Program Officer(s): Brigitte Sanders (NIAID) & Karen Lacourciere (NIAID)    

 

 

 

Immunotherapy

Room F1/F2

 

Moderator: Josh Leonard,  Northwestern University

NIH Program Officer(s): Anthony Welch (NCI)

 

 

 

 

*Please see room assignments under breakout session topic

11:00am - 11:30am       

Break and Breakout Summary Preparation

Lobby

11:30am - 12:15pm

Breakout Readout

Room E1/E2

12:15pm - 1:15pm    

Networking Lunch (Optional)

Room A/B
1:15pm - 2:00pm

Synthetic Biology at the NIH: Overview

Brief presentations from NIH ICs with interest in Synthetic Biology

Michelle Bond, NIGMS Program Director
Craig Hopp, NCCIH Deputy Director, Division of Extramural Research
Jerry Li, NCI Program Director
Mahua Mukhopadhyay, NICHD Program Officer
David Rampulla, NIBIB Program Director
Brigitte Sanders, NIAID Health Scientist Administrator
Michael Smith, NHGRI Program Director
Room E1/E2

2:00pm - 2:15pm                            

Break

Lobby
2:15pm - 3:15pm

IC Roundtable

Talk with NIH Program Officers about your research, grant mechanisms, and IC missions

Room E1/E2:

NIBIB and NIGMS

 

Room G1/G2:

NCI and NIAID

 

Room C1/C2:

NCCIH and NICHD

3:15pm - 3:30pm

Closing Remarks

Josh Leonard, Northwestern University

Room E1/E2

 

Logistics 2019

Hotel Information

There is a room block reserved for the 2019 Synthetic Biology Consortium Meeting at the Hyatt Regency Bethesda. Here's the link to reserve under the block. Alternatively, you are welcome to reserve a room at the Hyatt at a non-discounted rate or reserve a room at other local hotels such as the Bethesda Marriott, The Double Tree by Hilton Hotel Bethesda, the American Inn of Bethesda, or the Hilton Garden Inn of Bethesda

The Hyatt Regency Bethesda is located next to the Bethesda Metro Station on the Metro Red Line. The 2019 SBC Meeting venue at the NIH Main Campus is one metro stop (Medical Center Metro Station on the Red Line) or a 15-minute walk away. Click here for a map of the DC metro system.

Meal Information

You may either purchase your lunch from the Natcher Conference Center Cafeteria or you can pre-order a lunch box delivered to the conference venue. An email will be sent out to attendees containing information regarding ordering lunch closer to the meeting date. Lunch will be delivered to the Natcher Building Auditorium at 11:30am on Monday, October 28th, and at 11:30am on Tuesday, October 29th. We highly recommend that participants pre-order and pre-pay for a box lunch so that there is ample time for discussion and networking. Instructions to follow soon.

Orders must be received by 4pm. EDT Thursday, October 24th.

If you're looking for alternate food options, click here for a detailed list of all the restaurants in the Bethesda, MD area. 

Posters

Posters should be at most 4 ft x 4 ft in size. 

 

Campus / Local Information

This meeting will be held in the William H. Natcher Building / Building 45 on the NIH main campus in Bethesda, MD.

Room: Ruth L. Kirschstein Auditorium (presentations); Atrium (posters)

Please allow adequate time to get to the NIH main campus and to get through security at the NIH Gateway Center Entrance. You will need to state the purpose of the visit and obtain a visitor’s badge, so please bring a government-issued photo ID (driver's license, passport, green card, etc.). Please allow 20-30 minutes for taxis, Uber, or Lyft to arrive and ask to be picked up at the MEDICAL CENTER METRO STATION.